Welcome

 

News

 

Research

 

Lab Members

 

Publications

 

Location Map

 

Teaching & Jobs

 

Links & Tools

 

 
  Publications (last update May 2018)
 

2018

  • Specht S, Liedgens L, Duarte M, Stiegler A, Wirth U, Eberhardt M, Tomás A, Hell K*, and Deponte M*. (2018) A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast. Redox Biol. 15:363-74.

  • Staudacher V, Trujillo M, Diederichs T, Dick TP, Radi R*, Morgan B*, and Deponte M*. (2018) Redox-sensitive GFP fusions for monitoring the catalytic mechanism and inactivation of peroxiredoxins in living cells. Redox Biol. 14:549-56.


2017

  • Wezena CA, Alisch R, Golzmann A, Liedgens L, Staudacher V, Pradel G, and Deponte M. (2017) The cytosolic glyoxalases of Plasmodium falciparum are dispensable during asexual blood-stage development. Microbial Cell 5:32-41.

  • Djuika CF*, Staudacher V*, Sanchez CP, Lanzer M, and Deponte M. (2017) Knockout of the peroxiredoxin 5 homologue PFAOP does not affect the artemisinin susceptibility of Plasmodium falciparum. Sci. Rep. 7:4410.

  • Begas P*, Liedgens L*, Moseler A, Meyer AJ, and Deponte M. (2017) Glutaredoxin catalysis requires two distinct glutathione interaction sites.
    Nature Commun. 8:14835.

  • Wezena CA*, Krafczyk J*, Staudacher V, and Deponte M. (2017) Growth inhibitory effects of standard pro- and antioxidants on the human malaria parasite Plasmodium falciparum. Exp. Parasitol.180:64-70.



2016

  • Wezena CA, Urscher M, Vince R, More S, and Deponte M. (2016) Hemolytic and antimalarial effects of tight-binding glyoxalase 1 inhibitors on the host-parasite unit of erythrocytes infected with Plasmodium falciparum. Redox Biol. 8:348-53.



2015

  • Begas P, Staudacher V, and Deponte M. (2015) Systematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins. Chem. Science 6:3788-96.

  • Staudacher V*, Djuika CF*, Koduka J*, Schlossarek S*, Kopp J, Büchler M, Lanzer M, and Deponte M. (2015) Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins. Free Radic. Biol. Med. 85:228-36.

  • Deponte M and Lillig CH. (2015) Enzymatic control of cysteinyl thiol switches in proteins. Biol. Chem. 396:401-13.

  • Djuika CF, Huerta-Cepas J, Przyborski JM, Deil S, Sanchez CP, Doerks T, Bork P, Lanzer M, and Deponte M. (2015) Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites. Microbial Cell 2:5-13.



2014

2013

  • Djuika C, Fiedler S, Schnölzer M, Sanchez C, Lanzer M, and Deponte M. (2013) Plasmodium falciparum antioxidant protein as a model enzyme for a special class of glutaredoxin/glutathione-dependent peroxiredoxins. Biochim. Biophys. Acta 1830:4073-90.

  • Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya A, Lanzer M, and Deponte M. (2013) The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain. Antimicrob. Agents Chemother. 57:2114-20.

  • Eckers E, Petrungaro C, Groß D, Riemer J, Hell K, and Deponte M. (2013) Divergent molecular evolution of the mitochondrial sulfhydryl:cytochrome c oxidoreductase Erv in opisthokonts and parasitic protists. J. Biol. Chem. 288:2676-88.



2012

  • Deponte M*, Hoppe HC*, Lee M*, Maier AG*, Richard D*, Rug M*, Spielmann T*, and Przyborski JM*. (2012) Wherever I may roam: Protein and membrane trafficking in P. falciparum-infected red blood cells. Mol. Biochem. Parasitol. 186:95-116.

  • Eckers E and Deponte M. (2012) No need for labels: The autofluorescence of Leishmania tarentolae mitochondria and the necessity of negative controls. PLOS ONE 7:e47641.

  • Urscher M, More SS, Alisch R, Vince R, and Deponte M. (2012) Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1. FEBS J. 279:2568-78.

  • Eckers E, Cyrklaff M, Simpson L, and Deponte M. (2012) Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries. Biol. Chem. 393:513-24.

2011

  • Harner M, Neupert W, and Deponte M. (2011) Lateral release of proteins from the TOM complex into the outer membrane of mitochondria. EMBO J. 30:3232-41.

  • Urscher M, Alisch R, and Deponte M. (2011) The glyoxalase system of malaria parasites- Implications for cell biology and general glyoxalase research. Semin. Cell. Dev. Biol. 22:262-70.



2010

  • Urscher M, Przyborski JM, Imoto M, and Deponte M. (2010) Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization, and inhibition of Plasmodium falciparum glyoxalases. Mol. Microbiol. 76:92-103.

 

2009

  • Eckers E, Bien M, Stroobant V, Herrmann JM, and Deponte M. (2009) Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: The catalytic redox mechanism redux. Biochemistry 48:1410-23.

  • Sturm N, Jortzik E, Mailu BM, Koncarevic S, Deponte M, Forchhammer K, Rahlfs S, and Becker K. (2009) Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. PLoS Pathog. 5:e1000383.

  • Koncarevic S, Rohrbach P, Deponte M, Krohne G, Rahlfs S, and Becker K. (2009) The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification. PNAS 106:13323-8.

  • Deponte M and Hell K. (2009) Disulphide bond formation in the intermembrane space of mitochondria. J. Biochem. 146:599-608.

  • Urscher M and Deponte M. (2009) Plasmodium falciparum glyoxalase II: Theorell-Chance product inhibition patterns, rate-limiting substrate binding via Arg257/Lys260, and unmasking of acid-base catalysis. Biol. Chem. 390:1171-83.



2008

  • Mesecke N*, Mittler S*, Eckers E*, Herrmann JM, and Deponte M. (2008) Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insights into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins. Biochemistry 47:1452-63.

  • Mesecke N, Spang A, Deponte M, and Herrmann JM. (2008) A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance.
    Mol. Biol. Cell
    19:2673-80.

 

2007

  • Deponte M, Sturm N, Mittler S, Harner M, Mack H, and Becker K. (2007) Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I. J. Biol. Chem. 282:28419-30.

 

2006

  • Hiller N, Fritz-Wolf K, Deponte M, Wende W, Zimmermann H, and Becker K. (2006) Plasmodium falciparum glutathione S-transferase – structural and mechanistic studies on ligand binding and enzyme inhibition.
    Protein Science 15:281-9.

 

2005

  • Koncarevic S, Deponte M, Fritz-Wolf K, Meyer M, Urig S, Fischer M, Réau R, Davioud-Charvet R, and Becker K. (2005) Mass spectrometric analysis of human glutathione reductase modified by a gold-phosphole inhibitor.
    In Flavins and Flavoproteins 15:325-30.

  • Nickel C, Trujillo M, Rahlfs S, Deponte M, Radi R, and Becker K. (2005) Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite. Biol. Chem. 386:1129-36.

  • Deponte M and Becker K. (2005) Glutathione S-transferase from malarial parasites – structural and functional aspects. Methods Enzymol. 401:241-53.

  • Deponte M, Urig S, Arscott LD, Fritz-Wolf K, Réau R, Herold-Mende C, Koncarevic S, Meyer M, Davioud-Charvet E, Ballou DP, Williams CH, and Becker K. (2005) Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase. J. Biol. Chem. 280:20628-37.

  • Deponte M and Becker K. (2005) Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx. Mol. Biochem. Parasitol. 140:87-96. 

  • Akoachere M, Iozef R, Rahlfs S, Deponte M, Mannervik B, Creighton DJ, Schirmer H, and Becker K. (2005) Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Biol. Chem. 386:41-52.

  • Deponte M, Becker K, and Rahlfs S. (2005) Plasmodium falciparum glutaredoxin-like proteins. Biol. Chem. 386:33-40.

 

2004

 

2003

  • Rahlfs S, Nickel C, Deponte M, Schirmer RH, and Becker K. (2003) Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism. Redox Rep. 8:246-50.